http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2001503024-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J53-002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J53-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J43-006 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-565 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-58 |
| filingDate | 1997-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2001-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2001503024-A |
| titleOfInvention | 7α- (ξ-aminoalkyl) -estraditriene, process for its preparation, pharmaceutical preparation containing 7α- (ξ-aminoalkyl) -estraditriene and its use for the preparation of a medicament |
| abstract | (57) The present invention provides a compound of the formula I: [Wherein the side chain SK is a partial formula: (Wherein, m represents 4, 5 or 6, n represents 0, 1 or 2, x represents 0, 1 or 2, A represents a hydrogen atom or a C 1 -C 5 alkyl group, alkylene groups and D is either each represents a hydrogen atom, or a and B together - (CH 2) p - represents a (p = 2, 3, 4 or 5), or D represents a hydrogen atom, or a and D is an alkylene group together - (CH 2) q - represents a (q = 2,3 or 4), B represents a hydrogen atom, E is is or 1-5 positions fluorination of unsubstituted Represents an ethyl group, or the terminal substituent — (CH 2 ) 3 —E in the side chain is directly bonded to a sulfur atom or bonded to a sulfur atom via a monomethylene group, a dimethylene group or a trimethylene group. R 3 represents water or a substituted or unsubstituted aryl or heteroaryl group. A hydrogen atom or a hydrocarbon radical having up to 8 carbon atoms or a radical of the formula R 3 ′ —C (O) —, wherein R 3 ′ has a hydrogen atom or up to 8 carbon atoms It represents a hydrocarbon group or a phenyl group, R 11 is a hydrogen atom, a halogen atom or a nitrooxy group -O-NO 2, R 14, R 15 α, R 15 β, each R 16 alpha and R 16 beta hydrogen atom Or R 14 and R 15 α represent an additional bond or a methylene bridge, or R 15 β represents a methyl group, R 15 α represents a hydrogen atom, or R 15 α and R 15 β each represents a methyl group, or R 15 β and R 16 β together represent a methylene bridge, or R 16 α or R 16 β represents a halogen atom, or R 16 α and R 16 beta represents a methylidene group together, the remaining substituents R 14, R 15 α, R 15 β, R 16 α and R 16 β represents a hydrogen atom, and R 17 ′ represents a hydrogen atom, a C 1 -C 5 alkyl group, a C 2 -C 5 alkenyl group or a C 2 -C 5 alkynyl group or a trifluoromethyl at the α-position or the β-position. R 17 ″ represents a hydrogen atom or a partial formula: R 17 ″ ′ —C (O) —, wherein R 17 ″ represents a hydrogen atom or a hydrocarbon group having up to 8 carbon atoms. Or when R 17 ′ is in the α-position, R 17 ′ together with R 14 represents an ethano bridge, provided that A and B together form — (CH 2 ) p - represented no or a and D together - (CH 2) q - in the case does not represent a substituent R 11, R 14, R 15 α, R 15 β, R 16 α and R 16 beta of at least one substituted 7α- (ξ- aminoalkyl) represented by that of Moto not hydrogen atom] - estratrienes and the Est Regarding addition salts of physiologically compatible and triene and organic or inorganic acid. This novel compound is a compound having a remarkably strong antiestrogenic action. The compounds of the present invention are in part pure antiestrogens or, on the other hand, antiestrogens with estrogen partial action. Based on this spectrum of action, the novel compounds are suitable for the manufacture of medicaments for tumor therapy and hormone replacement therapy. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2004107353-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2006306896-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2006528226-A |
| priorityDate | 1996-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 270.