| abstract |
(57) [Summary] Formula (I) Wherein W is -CONHOH or -COOH, R 1 and R 2 are each hydrogen or an organic residue, R 3 is an organic group, and Q is a secondary or tertiary, Compounds that are amine derivatives of acyclic or cyclic amino groups) and pharmaceutically acceptable salts, solvates and hydrates thereof, include matrix metalloproteinases (MMPs) and tumor necrosis factors from cells. It is an inhibitor of the release of α (TNF). Thus, they are useful in the prevention, control and treatment of diseases involving MMPs or TNF, especially neoplastic and inflammatory diseases. Methods for their manufacture and drug compositions containing them are also described. |