| abstract |
(57) [Summary]nThe present invention provides compounds of the formula (i) Xaa-Yaa-Arg wherein Xaa is any amino acid residue and Yaa is Glu or Xaa is absent and Yaa excludes Pro. (Ii) Arg-Yaa-Xaa, wherein either Xaa is any amino acid residue and Yaa is Glu or Xaa is absent, and Yaa is any amino acid residue excluding Asn]; (iii) Xaa-Arg-Yaa, where Xaa is any amino acid residue and Yaa is Glu]; A) a peptide of Yaa-Arg-Xaa, wherein Xaa is any amino acid residue and Yaa is Glu, and derivatives thereof. And it relates to peptides and derivatives thereof exert an inhibitory activity against macrophage migration and / or macrophage phagocytic activity. In addition, the peptide and its derivatives exert an inhibitory activity on the ability of macrophages and T cells to adhere to extracellular matrix and / or fibronectin. This peptide and its derivatives exert inhibitory activity on humoral and / or cellular immune responses. The present invention further relates to the peptides and derivatives thereof, and compositions comprising them, including but not limited to joints, within the general central nervous system, specific lesions of the central nervous system, and others. And methods of use for inhibiting inflammation, including inflammation at immuno-privileged sites. |