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filingDate 1998-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2001-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2001500428-A
titleOfInvention Method for separating Bi from the solution of radionuclides
abstract (57) Abstract: In a method of separating 213 Bi from a solution of a radionuclide, the solution comprises a concentration of chloride ions and hydrogen ions adjusted to allow formation of chloride complexes. . The solution is then contacted with the anion exchange resin so that 213 Bi is absorbed from the solution and deposits on the anion exchange resin in the chloride complex. Other non-absorbing radionuclides, such as 225 Ra, 225 Ac and 221 Fr, are removed from the anion exchange resin using a scrub solution with HCl. To remove 213 Bi from the anion exchange resin, the anion exchange resin is washed using a stripping solution. The stripping solution containing no chloride ion and having a reduced hydrogen ion concentration destroys the chloride anion complex and releases 213 Bi as a cation. In a preferred embodiment of the present invention, the anion exchange resin is provided as a thin film that allows for very fast deposition and stripping of 213 Bi. A preferred stripping solution for the purification of 213 Bi for use in medical applications is sodium acetate, pH 5.0. 5 are mentioned. As 213 Bi is released from the anion-exchange resin, for receiving the 213 Bi, proteins and NaOAc which joins the bifunctional chelating agents in vivo.
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