| abstract |
(57) Abstract: A method for inhibiting squalene synthase by contacting the following hydrophobic region of squalene synthase with van der Waals to form a hydrophobic interaction. (1) Val179, Leu183, Met207, Gly208, Leu211, Tyr276, Phe2 A hydrophobic region consisting of 88 and Pro292, and (2) Phe54, Val69, Phe72, Tyr73, L eu76, Val179, Leu183 and Phe28 8 hydrophobic region. [Effect] By utilizing the hydrophobic interaction at the active center of squalene synthase, it is possible to easily select a compound that inhibits squalene synthase and to design a drug. Useful for development. |