| abstract |
The present invention relates to substituted benzylamines having excellent ileal bile acid transporter inhibitory activity, pharmacologically acceptable salts thereof, esters and other derivatives thereof. SOLUTION: General formula (I) [Wherein R 1 and R 2 are a C 6 -C 10 aryl group; R 3 and R 4 are hydrogen atoms; A is the above formula (A-1) or (A-2) (where B is a single bond, a C 1 -C 6 alkylene group; rings Ar 1 and Ar 2 Is 1 to 2 of oxo or thioxo Group having); pieces substituted heterocyclic group D is a group having a CH; E is a group having -NH-; F is C 1 -C 6 alkylene group; ileal bile acid transporter with a ' Porter inhibitor. |