| abstract |
PROBLEM TO BE SOLVED: To provide a compound having a vascular smooth muscle growth inhibitory activity which is strongly expected as a preventive or therapeutic agent for diseases such as restenosis after PTCA, and a pharmaceutical composition containing such a compound. . SOLUTION: Formula (I) (Where Y is an ethylene group, Z is S (O) p, etc., R 1 is C 3-10 cycloalkyl group, etc., R 2 is hydrogen atom, m is 1 An integer of 0 to 4, n is an integer of 0 to 3, p is an integer of 0 to 2, q Represents an integer of 1 to 4, respectively. A) a prostaglandin E derivative represented by the formula (I), a pharmaceutically acceptable salt thereof or a hydrate thereof; and a pharmaceutical composition containing the compound. |