| abstract |
(57) [Summary]nPROBLEM TO BE SOLVED: To provide a nicotinic acetylcholine α4 of the central nervous system. Selectively binds and activates β2 receptors to activate the brain Improves dysfunction, etc. and is useful as a preventive or therapeutic drug The provision of a compound for use.nSOLUTION: The following formula (I):nEmbedded imagen 中 where A 1 And A Two Is a hydrogen atom, even if it is substituted A good alkyl group, an optionally substituted aryl group, or Or an optionally substituted heterocyclic group, wherein X is- C (R 1 , R Two ) -C (R Three , R Four )-, -C (R Five ) = C (R 6 ) -, -C (R 7 , R 8 ) -C (R 9 , R Ten ) -C (R 11 , R 12 ) -Or -C (R 13 , R 14 ) -C (R Fifteen , R 16 ) -NH- (However, R 1 ~ R 16 Represents a hydrogen atom, a halogen atom, An optionally substituted alkyl group, an optionally substituted Represents a reel group or an optionally substituted heterocyclic group) The compound represented by｝ or its pharmacologically acceptable Salts and medicaments containing them as active ingredients. You. |