| abstract |
(57) [Summary] (Modification) A compound of the formula (A) is disclosed wherein R 1 is Is aralkyl or cycloalkyl; R 2 is cycloalkylmethyl, alkyl, or aralkyl; R 3 is hydrogen, alkyl, substituted phenyl (including p-phenoxy-phenyl), or fluorene; 4 is hydrogen, alkyl, substituted phenyls (including 1-alkyl-4-carboxy-substituted phenyls), alkyl carboxylic acids; R 5 is hydrogen or R 1 And R 5 together form a tetrahydroisoquinoline or piperidine ring). These compounds have an inhibitory effect on fructose-1,6-bisphosphatase (FBPase) and are used for the treatment and management of type II diabetes. |