abstract |
PROBLEM TO BE SOLVED: To provide an improved method for producing a 4-substituted resorcinol derivative and an intermediate compound useful for producing such a resorcinol derivative. SOLUTION: embedded image The compound of the formula (6) is a compound of the formula (5) or (5 ′): For example, 1,8-diazabicyclo [5.4.0] undec-7- in a suitable solvent such as N, N-dimethylformamide. It is obtained by treatment with a base such as ene at around room temperature. And treating the compound of formula (6) with, for example, triethylsilane in the presence of a Lewis acid such as boron trifluoride in a chlorinated solvent, followed by removal of the protecting group under suitable conditions, Alternatively, the compound of formula (6) is hydrogenated under standard conditions to give the compound of formula I (a). The compound of formula (7) can be prepared by converting the compound of formula (5) or (5 ′) or (6) to 1,8-diazabicyclo [5.4. In a suitable solvent such as N, N-dimethylformamide. 0] obtained by treatment with a base such as undec-7-ene at about 140 ° C. Compounds of formula I (b) can be prepared by standard hydrogenation conditions It can be converted to a compound of formula I (a). |