| abstract |
(57) [Abstract] (Modified) [Problem] To provide an external preparation having a novel application of a drug represented by tinidazole having a sulfone group among nitroimidazole compounds, and its composition, amount and formulation And the like, to provide an external preparation for treatment / prevention of psoriasis. An external preparation of the compound represented by the formula 1 is used for treating psoriasis. I found a preventive effect. Further, by forming a compound comprising the compound represented by the formula 1 and other known dermatological agents such as corticosteroids and antifungal agents, the amount of the known dermatological agents is smaller than the effective amount of a single agent as a single agent ( For example, it has been found that even if the ratio is 1/20 to 20), it has a therapeutic effect effective for psoriasis, and that no side effect due to the combination is observed. (In the formula, R 1 and R 2 each represent a linear or branched lower alkyl group having 1 to 6 carbon atoms which may be substituted; An integer of 4) |