| abstract |
(57) [Summary] (Modified) [Problem] To provide more effective antiallergic agents and anti-inflammatory agents by using highly safe proanthocyanidins. SOLUTION: As the above therapeutic agent, among proanthocyanidins having a wide molecular weight fraction, a molecular weight of 3000 or more, Desirably, proanthocyanidins having a molecular weight of 3,000 or more and 10,000 or less have a strong activity of inhibiting the release of chemical messengers such as histamine and serotonin. Also, those proanthocyanidins are capable of converting Ca 2+ to mast cells and / or basophils. Inhibiting Ca 2+ influx through channels and / or inducing NO production in mast cells and / or basophils, these mechanisms inhibit cell degranulation, resulting in histamine, serotonin And the release of chemical mediators such as leukotrienes. |