| abstract |
(57) Abstract: An aromatic sulfonamide derivative having excellent cell cycle inhibitory activity and more useful as an antitumor agent than conventionally known aromatic sulfonamide-based antitumor compounds. The task is to provide. SOLUTION: General formula (1) (Wherein ring A represents a substituted benzene or substituted thiophene, X represents a formula —CH ＝ CH— or the like, n represents 0 or 1, R 1 represents a hydrogen atom, C 1 − C 6 represents an alkyl or the like, R 2 is C 1 -C 6 represents an alkylene, Y is cyano, the formula -CONR 3 R 4 (R 3 and R 4 are H, hydroxy, C 1 -C 6 alkyl such as ) Or the formula —SO 2 NR 5 R 6 (R 5 And R 6 represent H, C 1 -C 6 alkyl). A) a sulfonamide derivative represented by the formula: |