| abstract |
(57) [Summary] (with correction) [PROBLEMS] To provide a preservative for ophthalmic solution which is highly safe and can be used in a wide pH range. An ophthalmic solution preservative containing polylysine and / or protamine, wherein the ophthalmic solution preservative is at least one selected from glycine, alanine, arginine and histidine. Or a basic or basic amino acid or a salt thereof. Polylysine, protamine, glycine, alanine, After adding arginine and histidine to the ophthalmic solution, respectively, the pH is adjusted to 7.0 using an aqueous solution of IN sodium hydroxide or 1N hydrochloric acid, and sterile purified water is further added to prepare an ophthalmic solution containing a preservative. I do. |