| abstract |
(57) [Problem] To provide an agent for treating or preventing COX-2 or a disease mediated by COX-2 and NFκB. SOLUTION: Formula I Wherein R 1 and R 4 are hydrogen or form a bond together, R 5 to R 8 independently represent hydrogen, hydroxy or methoxy, and R 7 is glucoside, rutinoside, mannoside. Represents a sugar substituent such as glucopyranosyl, apiosylglucoside, wherein R 2 and R 3 are hydrogen, hydroxyl, methoxy, or Wherein R 2 ′, R 3 ′, R 4 ′, R 5 ′ and R 6 ′ are each independently hydrogen, hydroxy or methoxy, provided that R 2 or Provided that R 3 is represented by an optionally substituted phenyl ring. ). Or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for treating or preventing COX-2 or a disease mediated by COX-2 and NFκB. |