| abstract |
[PROBLEMS] To provide an analgesic having ORL1-receptor agonist activity. SOLUTION: The compound of the general formula (1) or a pharmaceutically acceptable salt thereof. Wherein R 1 is unsubstituted or substituted cycloalkyl or cycloalkenyl, and A is unsubstituted alkyl or alkenyl, hydroxyalkyl, alkoxy- (C = O) or unsubstituted, substituted aryl, or aromatic- M is a single covalent bond, O, S, NH Y is a bicyclic carbocyclic ring or a bicyclic heterocyclic ring, or a spiro carbocyclic ring or a spiro heterocyclic ring, and Z 1 , Z 2 , Z 3 and Z 4 Is hydrogen or the like. |