abstract |
(57) Abstract: A simple method for producing a 9- (2-hydroxyalkyl) purine derivative and a 1- (2-hydroxyalkyl) pyrimidine derivative. SOLUTION: A 1,3-dioxolan-2-one derivative (1) is reacted with a purine derivative or a pyrimidine derivative in the presence of a fluorine salt such as cesium fluoride, 9- (2-hydroxyalkyl). A method for producing a purine derivative (4) or a 1- (2-hydroxyalkyl) pyrimidine derivative (5). Embedded image (Wherein R 1-4 represents a hydrogen atom, an alkyl group, an aralkyl group, an aryl group, etc., and X 1-6 represents a hydrogen atom, a halogen atom, an amino group, a hydroxyl group, an alkyl group, an alkoxy group, an alkylthio group, an alkyl Represents a carbonylamino group, etc.) |