| abstract |
(57) [Problem] To provide a method for producing a macrocyclic lactone with high yield and high productivity. SOLUTION: The hydroxycarboxylic acid ester represented by the formula (1) is subjected to an intramolecular esterification reaction. Embedded image (Integer integer wherein m is 5 to 10, n is the m + n is 11 to 16, X is -CH 2 -, - CH = CH -, - O-, -S- or -NH-, wherein R is (m + n + Shows the (AO) groups which are represented by p R 1 - 2) ~40 hydrocarbon group or. Here, AO represents an alkyleneoxy group having 2 to 4 carbon atoms, and p represents the average number of moles of alkylene oxide added. R 1 represents a hydrocarbon group and has a carbon number selected such that the total carbon number of the — (AO) p R 1 group is (m + n + 2) to 40. ) |