| abstract |
(57) [Summary] (Modified)n[Problem] B 2 Antagonist activity and human liver microso B with metabolic stability to 2 Receptor non-pepti Provide antagonists.nThe general formula (I):n Or a pharmaceutically acceptable salt thereof. [A is independently halogen; Y is-(CH 2 ) m −, − C (O)-or -S (O)-; R 1 And R 2 Is German Standing C 1-4 Alkyl; R 3 Is C 7-9 Bicycloal Kill, C 5-7 Azacycloalkyl or C 7-9 Aza Bicycloalkyl and the like; R 4 Is thiazolyl, imidazo Ryl or oxazolyl or the like; R 5 Is hydrogen or C 1 -4 Alkyl; m is 0, 1, or 2; n is 0, 1, 2, 3, 4 or 5] A pharmaceutical composition comprising the above compound. |