abstract |
PROBLEM TO BE SOLVED: To provide a compound having a more excellent antagonism against NK 1 receptor, NK 2 receptor and NK 3 receptor, and further having good oral absorption and good pharmacokinetics. I do. A compound of the following general formula (I) or a pharmaceutically acceptable salt, ester or other derivative thereof: {R 1 : alkyl, R 2 : substituted 5-membered nitrogen-containing heteroaryl, substituted nitrogen-containing 5-membered heterocyclyl, R 3 : substituted-aryl, substituted heteroaryl, A: CO, SO 2 , E: CH 2 , O, S, G: substitutable cycloalkane ring, substitutable cycloalkene ring, substitutable saturated heterocycle, Ar: substitutable aryl ring, substitutable heteroaryl ring, m: 1, 2, n: 2-4. }. |