| abstract |
(57) [Summary] (Revised) SOLUTION: A dioxolane derivative represented by the following formula (1) and a salt thereof. [Wherein A 1 and A 2 represent a divalent hydrocarbon group; 3 represents a single bond or a divalent hydrocarbon group; a 1 and a 2 represent —O— or —N (A 4 ) —; Q 1 and Q 2 represent a cyclic hydrocarbon group or a heteroaromatic group. shows; Q 3 Represents a hydrogen atom, a hydroxyl group, an alkyl group, an alkoxyl group, a cyano group, a heterocyclic group, a carbamoyl group, an acylcarbamoyl group or a carbosyl group; R 1 and R 2 each represent an alkyl group, or R 1 , R 2 and They form a carbonyl group with the carbon atom to which they are attached, or form an aliphatic ring. [Effect] The dioxolane derivative or a salt thereof exhibits a potent squalene synthetic oxygen inhibitory action and is useful as a medicament for preventing and / or treating hypercholesterolemia, hyperlipidemia or arteriosclerosis. |