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filingDate 1999-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_358b51a39dc0f045f74adff09e686e53
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publicationDate 2001-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2001172300-A
titleOfInvention Monoclonal antibodies, hybrid cells and methods for producing monoclonal antibodies
abstract (57) [Summary] [Problem] The following formula (I): {Where Z 1 is a residue derived from dienoic acid, an alkyl group, A substituted alkyl group, a hydrogen atom, and Z 2 are residues derived from dienoic acid, and represent an alkyl group, a substituted alkyl group, and a hydrogen atom (however, Z 1 and Z 2 are not simultaneously hydrogen atoms). R 1 and R 2 each represent a hydrogen atom, an alkyl group having 1 to 20 carbon atoms, a substituted alkyl group, or R 3 —X— (where R 3 represents an alkyl group having 1 to 20 carbon atoms, Group or DNA residue, -X- is -O- (O =) P (-O H) -group). A conjugate having a group represented by}, An object of the present invention is to provide a monoclonal antibody characterized by specific recognition. In particular, an adduct and a protein whose conjugate is obtained by adding 13-hydroxyperoxy-9 (Z) -11 (E) -octadecadienoic acid or a metabolite thereof to 2'-deoxyguanosine To prepare a hybrid cell obtained by fusing an Emiloma cell with an antibody-producing cell obtained from a thermostatic animal immunized with the antigen, and further culturing the hybrid cell. To obtain a monoclonal antibody from the culture solution.
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