| abstract |
(57) [Abstract] (Modified) [Problem] Useful for prevention / treatment / improvement of diseases and injuries, agents for improving the survival rate in transplantation, agents for preventing / suppressing / improving rejection, pretreatment agents for surgery, etc. Provide a novel heat shock protein inducer. A heat shock protein inducer containing geranylgeraniol as an active ingredient. Geranylgeraniol possesses four double bonds in the molecule and has a total of eight geometric isomers. Any of the isomers may be used, or a mixture may be used. Among them, more preferably, the all-trans form (2E, 6E, 10) represented by the following chemical formula (I) E-form) or a 2-cis form (2Z, 6E, 10E-form) represented by the following chemical formula (II). [Effect] This drug is used for cranial nerve disease, cardiovascular disease, fire extinguisher disease, metabolic disease, autoimmune disease, degenerative disease, ischemic nerve cell injury, ischemia / reperfusion injury, cystic fibrosis, malignancy Tumor, infectious disease, liver failure, renal failure, drug poisoning, heavy metal poisoning, It is a preventive, ameliorating, and therapeutic agent for radiation injury, ultraviolet radiation injury, biological invasion, or aging. |