| abstract |
(57) [Problem] To provide an antiviral agent having a high antiviral activity and less harmful side effects. SOLUTION: In the formula, R 1 , R 2 , R 3 , R 4 and R 5 independently represent a hydrogen atom, an aliphatic carboxylic acid residue or an aromatic carboxylic acid residue. And the concentration IC 100 that inhibits HIV-1 induced cytopathogenic effect (CPE) in MT-4 cells by 100% and the concentration C that reduces MT-4 cell survival by cell proliferation test The protein kinase C (P at a concentration of 10 ng / mL with a ratio r = CC 0 / IC 100 of 2 or more to C 0 An antiviral agent comprising, as an active ingredient, a phorbol derivative having 30% or less activation of KC). The agent is useful as an anti-HIV agent. |