| abstract |
(57) [Summary] (Modified)nPROBLEM TO BE SOLVED: To provide a novel 5-thia-W-substituted phenyl-pros A taglandin E derivative is provided.nSOLUTION: 5-thia-ω-substitution represented by the formula (I) A phenyl-prostaglandin E derivative,n R 1 is hydroxy, C1-6 alkyloxy, or NR 6 R 7 Group (in the group, R 6 And R 7 Is independently hydrogen Or C1-4 alkyl. ) And R 2 Is oxo, halogen or O-COR 8 Group (in the group, R 8 Is C1-4 alkyl, phenyl or phenyl (C1-4 alkyl). ) And R 3 Is Represents hydrogen or hydroxy; 4a And R 4b Is each independently hydrogen or C 1-4 alkyl And R 5 Represents a substituted phenyl group You. |