| abstract |
(57) [Summary] [Object] To find a novel substance related to the colorectal cancer suppressor gene APC, enable the control of APC, and control colorectal cancer. A novel protein M1 capable of binding to an APC gene product, particularly an armadillo repeat (Arm) site of the gene product, that is, a polypeptide consisting of the amino acid sequence represented by SEQ ID NO: 1 in the sequence listing, and a polypeptide of the polypeptide Polypeptide having a part, polynucleotide encoding the polypeptide or its complementary chain, vector containing the polynucleotide or its complementary chain, transformant having the vector, antibody against the polypeptide, production of the polypeptide And screening methods for inhibitors, antagonists and activators of M1 function and expression using the above-mentioned compounds, compounds provided by the methods, and pharmaceutical compositions for use in colorectal tumors utilizing these compounds・ Provide diagnostic means. |