| abstract |
PROBLEM TO BE SOLVED: To provide a compound useful not only as having a high metalloproteinase inhibitory activity, but also as a medicament, by dramatically improving the availability and biological activity of a drug in a living body such as oral absorbability. I will provide a. A pharmaceutical comprising a compound represented by the following general formula (I) or a salt thereof as an active ingredient: Wherein, R 1 represents hydrogen or a protecting group for a hydroxyl group, R 2 is a protecting group of hydrogen or an amino group, R 3, R 7, and R 8 are hydrogen, hydroxyl, etc. unsubstituted or substituted alkyl group, R 4 Is an unsubstituted or substituted alkyl group, R 5 is -OR 9 or -NR 10 R 11 , R 9 is hydrogen, an alkyl group which may be substituted, R 10 and R 11 are the same or different, Hydrogen, unsubstituted or substituted alkyl group, other substituent, R 6 is hydrogen, hydroxyl group, amino group or -XY group, X Represents oxygen, an alkylene group or a phenylene group, Y represents an -AB group or a -B group (A represents an alkylene group or another substituent, and B represents hydrogen, an amino group, or another substituent)] |