| abstract |
(57) [Problem] To provide an α-ketoamide derivative having a chymase inhibitory activity useful for prevention or treatment of a disease associated with chymase. SOLUTION: General formula (1) [In the formula, A represents a lower alkyl group having a substituent, a lower alkoxy group or an aromatic ring group, R 1 and R 2 are the same or different, and are hydrogen, a lower alkyl group which may have a substituent, An amino group which may have a substituent, a sulfamoyl group which may have a substituent, a carbamoyl group or a group having a substituent (a) (In the group (a), B represents a monocyclic heterocyclic group.) And a pharmaceutically acceptable salt thereof. |