| abstract |
(57) [Problem] To provide an external preparation for skin containing urea, which prevents decomposition of urea, has no change in pH even when stored for a long time, and does not reduce the effect of urea. Furthermore, a skin external preparation in which the moisturizing effect of urea is improved and skin irritation is reduced is obtained. SOLUTION: In a skin external preparation containing urea as an active ingredient, urea was stabilized by adding nucleotides and salts thereof. Further, by using a hydroxy fatty acid having 2 to 8 carbon atoms or a fatty acid having 2 to 6 carbon atoms and an ester of glycerin, urea is further stabilized, and the moisturizing effect of urea is further enhanced by using a hydroxy fatty acid in combination, The combined use of fatty acid and glycerin esters reduced the skin irritation caused by urea. |