abstract |
PROBLEM TO BE SOLVED: To provide a thiazole analog compound effective as an inhibitor for tyrosinase activity and an external preparation for skin containing the same. SOLUTION: In the following general formula (I), ring X represents formula (A) (wherein, R 1 represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group), or a formula ( B) (wherein R 2 is a hydrogen atom, a lower alkyl group, It means a lower alkoxy group or a halogen atom. Y represents a cyclic amino group or a formula (C) wherein n is an integer of 1 to 5, R 3 is a formula (D) (where R 4 is a hydrogen atom or a lower alkyl group, R 5 represents a hydrogen atom or a lower alkyl group). And the external preparation for skin containing the same. Embedded image |