Predicate |
Object |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-072 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5044 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-502 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5023 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6897 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
filingDate |
1997-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate |
2000-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
JP-2000517193-A |
titleOfInvention |
Cell-based drug screening for regulation of gene expression |
abstract |
(57) SUMMARY The present invention provides methods and compositions for screening for drugs that regulate gene expression in mammals. Specific experiments include (a) mammalian cells containing a knock-in mutation of a target natural allele encoding a reporter of gene expression (as shown in the figure), where expression of the reporter is (B) contacting a candidate drug under the control of the natural gene expression control sequence with a candidate drug under conditions that, if the drug is not present, express the reporter at the first expression level; The difference between the first and second expression levels indicates that the candidate agent is one that regulates gene expression. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2010200756-A |
priorityDate |
1996-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |