abstract |
(57) Abstract: erythromycin, in particular novel C-13 substituents R 1 (e.g., C 3 -C 6 cycloalkyl or cycloalkenyl groups) having a found appropriate in the presence of R 1 CO 2 H organisms Is prepared by fermentation. A preferred organism is Saccharopolyspora erythraea, preferably of the genus Saccharopolyspora, which contains an integration plasmid that can direct the synthesis of the desired compound. |