http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2000516235-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-80 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 1996-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2000-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2000516235-A |
| titleOfInvention | Non-ulcer-inducing analgesic / anti-inflammatory clonixin derivatives |
| abstract | (57) Summary The clonixin derivative of formula (I), or 4-nitroxybutyl clonixiate, is a novel non-ulcer-inducing analgesic / anti-inflammatory product, mainly with a surprisingly high anti-inflammatory effect As a result (2 times the clonixic acid), there is a very good balance between high analgesic / anti-inflammatory effects and low ulcerogenic adverse effects. Compound (I) is prepared by reacting 4-chlorobutyl clonixiate with silver nitrate in acetonitrile. 4-Chlorobutylchronixiate is prepared by the reaction of 1-bromo-4-chlorobutane with alkali clonixiate in acetonitrile. 4-Nitrooxybutyl clonixiate (I) is particularly useful as an active ingredient for treating pain and / or inflammation in mammals. |
| priorityDate | 1996-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 62.