http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2000515721-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-521 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-50 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 |
| filingDate | 1996-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2000-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2000515721-A |
| titleOfInvention | Lumen cholecystokinin-releasing factor |
| abstract | (57) [Summary] Intraluminal cholecystokinin releasing factor (LCRF) is a cholecystokinin (CCK) releasing protein isolated from rat intestinal secretions. Purified LCRF was characterized by molecular weight, partial amino acid sequence, and CCK releasing activity shown in in vivo studies of anti-LCRF antibodies in blocking the CCK releasing effect of LCRF. Binding studies demonstrated localization of duodenal, pancreatic, and whole pancreatic nerve fibers, sensory and nodular ganglion cell bodies, and adrenal medulla sympathetic fibers. LCRF appears to be a neuropeptide present in the enteric, parasympathetic, and sympathetic nervous systems, but not in the brain. LCRF-IR is also present in enterocytes at the tip of the small intestinal villi. Taken together, the present study indicates that LCRF is a neuropeptide that may have several functions in the gastrointestinal tract and other systems. Immunoaffinity studies and intestinal luminal infusion studies using antibodies raised against synthetic LCRF 1-6 show that LCRF releases CCK release in intestinal secretions that mediates negative feedback regulation of pancreatic enzyme secretion and CCK release. Indicates that it may be a peptide. LCRF and functionally related species have the potential to develop treatments for insulin secretion, to treat stomach and gallbladder emptying, and to develop regimens that require appetite control or suppression. |
| priorityDate | 1995-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 848.