| abstract |
(57) [Summary]nThe present invention relates to special adamantyl or adamantyl group derivatives containing a retinoid compound which induces apoptosis of cancer cells. These adamantyl retinoid derivatives can be used for various cancers and solid tumors, especially for androgen-independent prostate cancer, skin cancer, pancreatic cancer, colon cancer, melanoma, ovarian cancer, liver cancer, small cell lung cancer, non-small cell lung cancer, cervical cancer. , Breast cancer, bladder cancer, brain cancer, neuroblastoma / glioblastoma, and leukemia. The present invention also relates to novel adamantyl or adamantyl group derivative compounds useful as active agents for the treatment or prevention of keratinization and other dermatological conditions, and other diseases. |