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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496
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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06
filingDate 1998-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2000-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2000513747-A
titleOfInvention HIV protease inhibitor sulfate with improved oral absorption and bioavailability
abstract The present invention relates to sulfates of compound (A), an HIV protease inhibitor that is effective in treating AIDS, ARC or HIV infection in adults and children. More specifically, the present invention relates to a compound (A) that is an HIV protease inhibitor that has significantly improved solubility in dilute hydrochloric acid (gastric acid) solution, thereby greatly increasing oral absorption and bioavailability in animal models. ) Is provided. Also disclosed are methods for making sulfates of certain HIV protease inhibitor compounds.
priorityDate 1997-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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