http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2000512494-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-111 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-15 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4746 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4738 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y303-02009 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| filingDate | 1997-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2000-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2000512494-A |
| titleOfInvention | Cell growth regulatory gene |
| abstract | (57) Abstract Transcriptionally regulated growth response genes play a central role in determining cell fate. p53 has been shown to transcriptionally regulate genes important in regulating cell proliferation. Using differential RT-PCR analysis of rat embryonic fibroblasts containing a temperature-sensitive p53 allele, we isolated several transcripts that are specifically positively regulated in cells harboring wild-type p53 protein We were able to. Two of these genes, SM20 and microsomal epoxide hydrolase (mEH), are previously described genes. Two previously uncharacterized cDNAs, the cell growth regulation (CGR) genes CGR11 and CGR19, were isolated. The predicted amino acid sequences of these novel proteins include known motifs, namely, the EF hand domain (CGR11) and the ring finger domain (CGR19), which suggests function. CGR11 and CGR19 appear to be early response genes expressed at 0.05% and 0.01% of total mRNA in wild-type p53 cells. Both CGR11 and CGR19, like SM20 and mEH, can inhibit the growth of some cell lines. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006098304-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008063244-A |
| priorityDate | 1996-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 167.