abstract |
(57) [Summary]nA method for screening compounds to identify compounds that inhibit or otherwise modulate presenilin-1 (PS-1) cleavage, comprising determining the extent of cleavage of PS-1 into 18 kDa and 28 kDa species by a test compound. , A method of measuring relative to the extent of cleavage in the absence of, the compound identified thereby and the use of the compound in therapy. |