http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2000510871-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1272 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-543 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-88 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
| filingDate | 1998-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2000-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2000510871-A |
| titleOfInvention | Novel lipid compounds which can be used to transfer at least one active substance, in particular polynucleotides, into target cells and compositions containing them and their use in gene therapy |
| abstract | (57) Abstract: The present invention relates to novel lipid compounds of the formula: R-HN - [- ( CH 2) m -NR-] n-1 - (CH 2) m -NH-R (I) { wherein The middle R residues are, independently of one another, a hydrogen atom or a group of the formula II: [Wherein, R 1 and R 2 independently represent a linear or branched C 6 -C 23 alkyl or alkenyl group, or a linear or branched group —C (＝ O) — (C 6 -C 23 ) alkyl or -C (= O) - (C 6 -C 23) alkenyl, aryl group, cycloalkyl group, fluoroalkyl group, polyethylene glycol group, optionally substituted, optionally repeating linear or branched oxyethylene or An oxymethylene group, p is a positive total integer of 1 to 4, n is a positive total integer of 1 to 6, m is each-(CH 2 ) m -NR- unit, more specifically n> 1 Where each — (CH 2 ) m —NR— unit may be different and the total number of positive integers from 1 to 6, the number of R groups of formula II is from 1 to 4]. A form that is biologically acceptable It is used in combination with two or more types of anion. The present invention also relates to a novel complex comprising at least one kind of the above-mentioned cationic compound and a negatively-charged active substance for introducing the above-mentioned active substance into cells. In particular, the invention relates to novel complexes where the active substance consists of one or more nucleic acids useful for cell transfection. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2006503860-A |
| priorityDate | 1997-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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