| abstract |
(57) [Summary] 1. A compound represented by the following general formula (i): Wherein X represents CO or CS, R represents H, a halogen atom or alkyl, R 1 represents alkoxy, OH or thioalkyl optionally substituted by one or more halogen atoms; R 2 , R 3 and R 4 may be the same or different and are each H, R 7 , OR 11 , COR 7 , C (（NOR 7 ) R 7 , alkyl-C (＝ NOR 7 ) R 7 , alkyl -C (= NOH) R 7, C (= NOH) R 7, halogen, CF 3, CN, CO 2 H, CO 2 R 11, CONH 2, CONHR 7, CON (R 7) 2, NR 9 R 10 or CONR 12 R 13 (where NR 12 R 13 represents a heterocyclo ring optionally substituted by one or more R 15 ), and R 5 represents H, arylalkyl, heteroaryl Alkyl, Hete B cycloalkyl, S (O) mR 11 or alkyl (said groups hydroxy, alkoxy, CO 2 R 8, SO 2 NR 12 R 13, CONR 12 R 13, CN, carbonyl oxygen, NR 9 R 10, COR 11 and S (O) nR 11 , optionally substituted with one or more groups selected from the group consisting of: R 6 is aryl, heteroaryl, heterocyclo, arylalkyl, heteroarylalkyl or Denotes heterocycloalkyl, wherein at R 5 and / or R 6 the aryl / heteroaryl / heterocyclo moiety may be optionally substituted by one or more alkyl-R 14 or R 14 . The compounds can be used to treat disease states, such as those associated with proteins that mediate cellular activity, for example, by inhibiting tumor necrosis factor and / or phosphodiesterase IV. |