| abstract |
(57) [Summary]nNovel peptides are described that bind to uPAR and can inhibit the binding of integrins and vitronectin. Also provided are nucleic acid sequences encoding the novel peptides. Methods for screening for small molecules, other peptides, or peptoids that mimic the antagonistic function of the peptides of the invention are described. The present invention relates to disorders characterized by up-regulation of uPA and uPAR, as well as applications in the design of therapeutics to treat cancer and chronic inflammation, cell migration or uPAR: integrin binding interactions, and diagnostics for these disorders Have a strategic application. |