| abstract |
(57) [Summary]nProvided are nucleic acid compositions encoding a family of mammalian proteins expressed in the retina and brain. Members of the gene family are generally genetically linked to various sensory neuropathies, including cochlear degeneration, peripheral retinal degeneration, and cone-rod retinal dystrophy. The nucleic acid compositions are used to identify DNA sequences encoding homologous or related proteins, produce the encoded proteins, and study related physiological pathways. In addition, modulation of gene activity in vivo is used for prophylactic and therapeutic purposes, such as treating sensory neuropathy, identifying retinal cells based on expression. The DNA is further used as a diagnostic for a genetic predisposition to linked sensory neuropathy. |