| abstract |
(57) Abstract: Disclosed is 3-imino-4-oxo-1,7-diacid (7-N-hydroxy) diamide, which has an oxymethyl group at the 6-position. Preferred compounds are those of the formula I wherein R 1 is a substituent of the formula II: A- (O-CR 5 H) n ) m -O-CH 2- Having. AR 2 , R 3 , R 4 , R 5 , m and n are as defined in the description. The compounds are useful, for example, as medicaments for inhibiting TNF release and treating autoimmune and inflammatory diseases such as multiple sclerosis and rheumatoid arthritis. Also provided are processes for preparing these compounds, and intermediates therefor and pharmaceutical compositions containing them. |