abstract |
(57) [Summary]nThe present invention provides a polynucleotide (cdap) that identifies and encodes a human cell death-related protein isolated from a rheumatoid synovial membrane library. The present invention provides genetically engineered expression vectors and host cells comprising a nucleotide sequence encoding CDAP. The invention also provides for the therapeutic use of purified CDAP, cdap, or an antisense molecule thereof or a CDAP inhibitor in a pharmaceutical composition, and for the treatment of conditions or diseases involving the expression of CDAP. The invention further describes a diagnostic test using a diagnostic composition comprising an antibody that specifically binds to the polynucleotide, fragment thereof, or polypeptide. |