| abstract |
(57) SUMMARY A method for obtaining a beneficial stable level of circulating histamine for use in a method for enhancing the cytotoxicity of a cytotoxic effector cell is disclosed. In such methods, beneficial levels of circulating histamine are obtained, and an agent is administered whose histamine increases its ability to enhance the cytotoxicity of natural killer cells. Alternatively, stable beneficial levels of circulating histamine are obtained in patients receiving chemotherapy or antiviral therapy. The present invention may further be used in treatments that combine histamine, agents that enhance cytotoxicity of cytotoxic effector cells, and chemotherapeutic agents. Optimization of the supply of substances that trigger the release of histamine and endogenous histamine has also been disclosed. |