| abstract |
(57) [Summary]nThe present invention relates to a non-immunogenic cell composition, comprising a cell surface and a cell having an antigenic determinant on the cell surface, and an optional linkage covalently attached to the cell surface. And a non-immunogenic compound (eg, polyethylene glycol or a derivative thereof) directly and covalently attached to a conjugate molecule or cell. In certain embodiments, the conjugate molecule is covalently attached directly to an antigenic determinant on the cell surface. In yet another embodiment, the conjugate molecule may be covalently attached to a non-antigenic site on the cell surface. In addition, by various uses of the non-immunogenic cells thus obtained, a method for reducing phagocytosis of cells, a method for reducing side reactions to blood transfusion, and a method for reducing transplanted cells, tissues, or organs Methods are provided for reducing rejection, reducing antibody-induced aggregation of cells, and the like. |