| abstract |
(57) [Summary]nThe present invention relates to periosteum / perichondrium tissue that can hold a scaffold in place and provide a source of chondrogenic progenitor, chondrocytes and other stromal cells for attachment to the scaffold in vivo. In combination, the present invention relates to a method of cartilage formation and / or repair in vivo, comprising inserting a biocompatible, non-living, three-dimensional framework or framework into a patient at the site of cartilage damage or loss. In addition, a preparation of cells, including chondrocytes, cartilage progenitor cells or other stromal cells, is applied before, during or after insertion of the skeleton and / or periosteum / perichondrium tissue; Applied directly to the insertion site in vivo to form new cartilage at the site, to transfer cartilage formation and chondrocytes, cartilage progenitor cells and other stromal cells from the adjacent in vivo environment to the skeleton. Promotes induction of the promoting factor. |