http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2000505114-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0433 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-46 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-04 |
| filingDate | 1997-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2000-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2000505114-A |
| titleOfInvention | Method for producing 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylic acid derivative |
| abstract | (57) Abstract: The present invention relates to a method for producing a nonionic iodinated contrast agent which is a derivative of 5-amino-1,3-benzenedicarboxylic acid and has a hydroxyl-substituted acylamino residue at the 5-position. Thus, without isolating any intermediate, it relates to a process comprising the following steps: (a) 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylic acid dichloride was protected as an ester Reacting with an acyl chloride having a hydroxyl group to obtain a solution of 5-acylamino-2,4,6-triiodo-1,3-benzenedicarboxylic acid dichloride in dimethylacetamide; (b) step (a) In the crude solution obtained from the above, a compound represented by the formula: NR 1 R 2 R 3 wherein R 1 , R 2 and R 3 are each independently a (C 1 -C 12 ) linear or branched alkyl group, (C 1 ~ 3) a tertiary amine represented by alkyl (C 6 -C 10) aryl radical or (C 1 -C 4) alkenyl group], while maintaining the reaction temperature at 0 to 30 ° C., the molar amount of acyl chloride (C) adding the amino alcohol to the solution obtained from step (b) to give the corresponding N, N'-bis [2,4,6-triiodo-1 , 3-benzenedicarboxamide], which is directly hydrolyzed to deprotect the protected hydroxyl group. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7012722-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2018517705-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012509290-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2011518878-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2021102628-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019535802-A |
| priorityDate | 1996-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 106.