http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2000505081-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-20 |
| filingDate | 1996-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2000-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2000505081-A |
| titleOfInvention | Solid phase synthesis of oligonucleotides N3 '→ P5' phosphoramidate |
| abstract | (57) [Summary]nThe present invention provides a method for synthesizing oligonucleotides N3 ′ → P5 ′ phosphoramidates using a phosphoramidite amine exchange reaction, wherein the deprotection 3′-amino acid of the solid support oligonucleotide chain is provided. The group is exchanged for the amino moiety of the 5'-phosphoramidite of the incoming monomer having a protected 3'-amino group. The resulting internucleoside phosphoramidite linkage is then oxidized to form a stable protected phosphoramidate linkage. The process of the present invention greatly improves product yields and reduces reagent usage over currently available synthetic methods for compounds of the above type. |
| priorityDate | 1996-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 228.