| abstract |
(57) [Summary]nThe present invention relates to perfluoro lower alkyl derivatives of amino acids. A novel synthetic route to α-aminotrifluoromethyl ketones is provided, which consists of converting an α-amino acid to oxazolin-5-one and then reacting with Ruppert's reagent. Fluorinated derivatives of amino acids and peptides have been shown to have novel properties of inhibiting or inactivating metallo-β-lactamase enzymes, ie, are valuable components of antibacterial formulations. Certain trifluoromethyl derivatives of amino acids are novel compounds per se. |